45 Prime Chem
Metabolism

Retatrutide

The next step in the evolution of metabolic peptides.

If Semaglutide works with one hormone and Tirzepatide with two, Retatrutide was designed to act on three of the body's natural systems.

What is it?

A peptide that activates three different receptors —GLP-1, GIP and glucagon—, each with a distinct role in energy balance. It brings together three natural signals in a single molecule.

How does it work?

After eating, the body uses different hormones to regulate hunger, glucose and energy use. Retatrutide activates three of those pathways at once: like going from a two-cylinder engine to a three-cylinder one.

What science is researching

Appetite regulation Body weight management Glucose control Energy expenditure Metabolic health

Observed results

Results may vary from person to person and depend on the context of the study.

  • A greater feeling of fullness
  • Reduced appetite
  • Significant changes in body weight in some studies
  • Improvements in metabolic markers in the populations studied

What it does NOT do

  • It does not replace healthy habits
  • It does not remove the need for medical supervision when appropriate
  • It does not guarantee the same results for everyone
  • It is still under investigation for several applications

Is it for you?

If you're interested in learning about:

  • Advanced metabolism
  • Obesity research
  • Appetite regulation
  • Energy expenditure
  • New generations of peptides

Quick summary

Category
Metabolism
Type
Triple agonist
Function
Activates GLP-1, GIP and glucagon
Research
Body weight, metabolism and glucose
Status
In clinical research
Did you know?

It is known as a triple agonist because it interacts with three receptors in a single molecule, a combination that until a few years ago did not exist in one peptide.

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